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Kishanpal Shakya*, Dr. Dilip Agarwal, Mr. Rakesh Goyal, Ashok Kumar Sharma, Mohit Khandelwal


Sublingual tablets Purpose: Sublingual drug delivery are often an alternate and better route in comparison to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is usually desired for a few drugs, especially those utilized in the treatment of acute disorders. Sublingual tablets disintegrate rapidly and therefore the bit of saliva present is typically sufficient for achieving disintegration of the dosage form including better dissolution and increased bioavailability. Published articles from PubMed and other standard sources were utilized to review and compile an summary of sublingual tablets and therefore the benefits of the sublingual route of administration. Sublingual tablets were found to possess better characteristics in comparison to standard dosage forms. Sublingually administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties thanks to fast disintegration. The addition of super-disintegrants facilitated rapid disintegration and this approach are often wont to treat acute disorders or emergency conditions. Sublingual tablets or any sublingual dosage form are often wont to achieve a rapid onset of action, better patient compliance and increased bioavailability. The sublingual route of administration are often used for drugs which undergo extensive first pass metabolism or degradation within the GIT. Drugs administered sublingually tend to possess better bioavailability which correlates to dose reduction in comparison to standard oral tablets.

Keywords: Easy self-medication; Fast disintegration; Increased bioavailability.

[Full Text Article]

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