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Abstract

A REVIEW ON DETERMINATION OF RESIDUAL SOLVENTS BY USING DIFFERENT CHROMATOGRAPHY CONDITION IN OMEPRAZOLE API BY HEADSPACE GAS CHROMATOGRAPHY

Ramanpreet Kaur*, Pooja, Dr. Satvinder Kaur and Dr. Anu Jindal

ABSTRACT

This review is compilation of various techniques for measurement of residual solvent by headspace gas chromatography for Omeprazole drug. The measurement of residual solvent content is essential for all active pharmaceutical ingredients (API) according to the good manufacturing practices. In pharmaceutical samples, residual solvents can be monitored by using gas chromatography with headspace. Different chromatographic conditions include carrier gas, flow rate, detector temperature, injector temperature, loop temperature, transfer line temperature, GC cycle time. As per the ICH guidelines, validation parameters were performed for those developed methods.

Keywords: Omeprazole, Residual solvent, HSGC, ICH.


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