IMMUNOMODULATORY POTENTIAL OF SALIVARY GLAND EXTRACTS OF OCTOPUS
Gayathri Narayan*, Asha Rao, Manekar A.P.
ABSTRACT
Marine environment is emerging as a source for diverse and novel chemical structures such as bioglycan, cyclic tripeptides, polyhydroxylated lactone, polysaccharides, terpenes, etc. with promising biological activities. Secondary metabolites from marine organisms have been found to possess several activities including antimicrobial, anti-proliferative, analgesic and immunostimulation. The present study was designed to study the immunomodulatory effects of the posterior salivary gland extracts of two species of octopus – Cistopus indicus and Octopus fusiformis. The glands were extracted in three solvents, partially purified and the samples assayed for hemagglutination, delayed type hypersensitivity response and phagocytosis. The observations made in the present study suggest that the extracts of the salivary glands of these two octopus species show variations in their activities. The acetic acid, methanol extracts and the fractions FA4, FA5, FA6, FA7, FA10 of the salivary glands of C. indicus showed significant immunomodulatory effect.
Keywords: immunomodulation, octopus, salivary gland.
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