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Rohit Sharma*, Preeti Kush and Aishwarya Gangwar


In modern drug discovery techniques, there has been a consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. The self-micro emulsifying drug delivery system (SMEDDS) was planned for defeating the issues of poor solubility and bioavailability. It is discovered that 40% of active substances are ineffectively water-soluble and lack of dose uniformity. It is an incredible challenge to change over those molecules into an orally administered formulation with adequate bioavailability. SMEDDS has shown a successful approach for improving the bioavailability of poorly water-soluble and lipophilic drugs. SMEDDS is ideally an isotropic mixture of oils and surfactants and sometimes co-solvents/surfactants. It can be orally administered in soft or hard gelatin capsules. When compared with simple emulsions, which are sensitive and metastable dispersed forms, SMEDDS are physically stable formulations that are easy to manufacture. Many parameters like surfactant concentration, oil/surfactant ratio, the polarity of the emulsion, droplet size, and charge play a critical role in the oral absorption of the drug from SMEDDS.

Keywords: Self-micro emulsifying drug delivery system (SMEDDS), lipophilic drugs, Bioavailability, surfactant concentration, oil/surfactant ratio, polarity, droplet size, charge.

[Full Text Article]

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