Abstract

FAST DISSOLVING SUBLINGUAL FILM-A NEW APPROACH TO ORAL DRUG DELIVERY SYSTEM: A REVIEW

Garima Thapliyal* and G. Gnanarajan

ABSTRACT

Sublingual route is a very useful for rapid onset of action with better patient compliance. It improves the efficacy of API’s and provides better drug utilization. Many patients are problematic to swallow capsule and tablet mostly for pediatric and geriatric patients. These formulations are suitable for cold, allergic rhinitis, asthma attacks, CNS disorders where rapid onset of action is required for faster relief. In some cases such as abrupt episode of allergic attack, motion sickness, dread of choking and an unattainability of water the swallowing of tablet and capsule is difficult. To overcome these difficulties, fast dissolving sublingual film is established. The sublingual route of drug administration is very effective since the drug absorbed through the sublingual blood vessels by passes hepatic first pass metabolic process and gives a better bio-availability. The present article outlines the definition viewpoints, Advantages manufacturing methods like solvent casting method, evaluation parameters and of fast dissolving films by sublingual route.

Keywords: Sublingual route, patient compliance, allergic rhinitis, asthma attacks, faster relief, bio-availability.