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Abstract

CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF VERNONIA POLYANTHES (SPRENG.) LESS. (ASTERACEAE)

Tayane Fardim Correa*, Fernanda Leite Pereira Martins, Rodrigo Rezende Kitagawa, Ricardo Machado Kuster, Álvaro Cunha Neto, Beatriz Gonçalves Brasileiro, Damaris Silveira and Claudia Masrouah Jamal

ABSTRACT

A phytochemical investigation on the aerial parts of Vernonia polyanthes Less (Asteraceae) led to the identification and/or isolation of Elemol (1), β-Eudesmol (2), 9,12-Octadecadienoic acid, ethyl ester (3), ethyl palmitate (4), β-Sitosterol (5), β-Amyrin (6), lupeol (7), (3α)-Olean-12-en-3-yl acetate (8), lupeol acetate (9), α-amyrin acetate (10) and α-amyrin (11). Their structures were elucidated by spectroscopic methods and mass spectrometry. Crude extract and compounds 7, 9-11 were evaluated for their ability to inhibit the α-amylase enzyme. The isolated compounds showed a statistically similar capacity to inhibit the enzyme in comparison to the crude extract (27.41 %). The extract promoted 14.77 % of clot lysis in the in vitro thrombolytic assay and presented antioxidant activity in ABTS and DPPH methods, with IC50 of 19.73 and 33.25 μg/mL respectively. The compounds 1, 2 and 7 can explain the primary antioxidant activity detect.

Keywords: Vernonia polyanthes; assa-peixe; CG-MS; Antioxidant activity; ?-amylase; Thrombolytic.


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