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Abstract

BIO-EQUIVALENCE STUDY OF TWO ORAL FLORFENICOL PRODUCTS (HUVEFLOR® AND SOLOFLOR 20%®) IN CHICKENS

Ashraf Elkomy* and Mohamed Aboubakr

ABSTRACT

The comparative bio-equivalence of Huveflor® and Soloflor 20%® in broiler chickens was studied after oral administration of both products in a dose of 10 mg florfenicol/kg b.wt. Twenty four broiler chickens were divided equally into two groups (12 chickens for each group). The first group was designed to study the pharmacokinetics of Huveflor®, while the 2nd group was designed to study the pharmacokinetics of Soloflor 20%®. Each broiler chicken in both groups was orally administered with 10 mg florfenicol/kg b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration. The disposition kinetics of florfenicol in Huveflor® and Soloflor 20%® following oral administration of 10 mg florfenicol/kg b.wt, revealed that the maximum blood concentration [Cmax] were 14.49 and 13.95 μg/ml and attained at [tmax.] of 2.10 and 2.12 hours, respectively. Florfenicol in Huveflor® and Soloflor 20%® was eliminated with half-lives [t1/2el] equal to 4.63 and 4.39 hours, respectively. It was concluded that Soloflor 20%® is bioequivalent to Huveflor® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) were 0.96, 0.95 and 0.94 respectively. These are within the bioequivalence acceptance range. Huveflor® and Soloflor 20%® are therefore bioequivalent and interchangeable.

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