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Abstract

BIOEQUIVALENCE STUDY OF TWO ORAL CHLORTETRACYCLINE HYDROCHLORIDE SOLUBLE POWDER (AUREOMYCIN® AND CURACHLOR®) IN BROILER

Ashraf Elkomy* and Mohamed Aboubakr

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Aureomycin® and Curachlor® in healthy broiler chickens after oral administration of both products in a dose of 20 mg chlortetracycline/Kg b.wt. Twenty four broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Aureomycin®, while the 2nd group was designed to study the pharmacokinetics of Curachlor®. Each broiler chicken in both groups was orally administered with 20 mg chlortetracycline/Kg b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 8, 12 and 24 hours after a single oral administration. The disposition kinetics of Aureomycin® and Curachlor® following oral administration of 20 mg chlortetracycline/Kg b.wt, revealed that the maximum blood concentration of chlortetracycline [Cmax] were 2.73 and 2.58 μg/ml and attained at [tmax] of 0.79 and 0.75 hours, respectively. In conclusion: Curachlor® is bioequivalent to Aureomycin® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) was 0.94, 0.89 and 0.90 respectively. These are within the bioequivalence acceptance range. Curachlor® and Aureomycin® are therefore bioequivalent and interchangeable.

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