Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

RADIOIODINATION AND BIOLOGICAL EVALUATION OF PARATHION AS A NEW RADIOTRACER TO STUDY IN EXPERIMENTAL MICE

M. H. Sanad, Abdel Rahim E. A., Rashed M. M., A. S. M. Fouzy*, Omaima A. Hussain, F. A. Marzook and S. M. Abd-Elhaliem

ABSTRACT

Up till now there are no studies on the distribution of Iodine- Labeled pesticides in mice or even rat organs, therefore the aim of this study is to trace radioiodinated parathion pesticide in experimental animals in experimental animals. The present work was oriented to synthesis of radioiodinated parathion (PA) for imaging. The radiotracer, parathion was labeled with [125I] using chloramine-T (Ch-T) as an oxidizing agent. Many factors were systematically studied to maintain high radiochemical yield of the [125I]PA reaching values of 98.5%. The radiotracer was completely separated and purified using high performance liquid chromatography (HPLC). The biological distribution indicated that The radiotracer, [125I]PA can be used as a tracer to image different target organs specially liver and kidneys, whereas results recorded 25.11 ±0.19 % and 28.6 ±0.77 % after 2 hours.

Keywords: Parathion, 125I – Labeling - biological distribution - Imaging.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More