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Abstract

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF TRAMADOL HYDROCHLORIDE IN MICE MODEL

*R.Naga Kishore1, N.Anjaneyulu1, M.Naga ganesh1, N.Sravya1, G.Abhinayani1, and C.Pratyusha1

Department of pharmacology, Geethanjalicollege of pharmacy, Cheeryal (v), Keesara (m), R.R.Dist, India

ABSTRACT

Present study was designed to investigate the anti depressant activity of the tramadol. Anti-depressant activity evaluated by forced swim test, tail suspension test and open field test. Healthy albino mice (6-7 week old) weighing 20- 40- grams were used. Potency of the test sample was compared with the standard fluoxetine drug. Results showed that the administration of the tramadol produced adiminution of immobility time (a posture thought to reflect a state of ‘‘behavior despair’’ in which animals have given up the hope to escape) of mice exposed to the both forced swimming and tail suspension tests. In the present study, tramadol (50 mg/kg, ip) administered to mice, produced significant antidepressant‐like effect in both TST and FST and efficacy was found to be comparable to fluoxetine (20 mg/kg, ip). Further studies would be necessary to evaluate the contribution of tramadol for the observed antidepressant activity as it still remains to be determined for the side effects.

Keywords: Tramadol, Fluoxetine, Open Field Test, Forced Swim Test, Tail Suspension Test.


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