Abstract

FREQUENCY OF ADVERSE DRUG REACTIONS ACCORDING TO ORGAN SYSTEM INVOLVED AND RESULTING ALTERED SERUM BIOCHEMISTRY IN PATIENTS ON ANTI-PSYCHOTIC DRUGS IN OUT-PATIENT DEPARTMENT OF A PSYCHIATRY HOSPITAL IN KASHMIR; A PROSPECTIVE OBSERVATIONAL STUDY

Dr. Afkat Ahmad, Dr. Sameena Farhat and Dr. Shakil U. Rehman*

ABSTRACT

Antipsychotic drugs have a high therapeutic index and are generally safe agents. Adverse effects often are extensions of many pharmacological actions of these drugs. The most important are those on the cardiovascular, central, autonomic nervous system and endocrine systems.. It was a prospective observational study conducted over a period of one year in Out-Patient department of Institute of Mental Health and Neurosciences (IMHNS), Government Medical College Srinagar. Causality assessment was done using WHO-UMC scale and Naranjo’s Scale while severity by using modified Hartwig and Siegel scale. Chi-square test was used to test for the independence of two categorical variables. A total of 100 ADRs were reported by 77 patients. The most common ADR was increase in weight (in 10.7% patients) followed by increased appetite (in 6.8% patients), sedation (in 5.6% patients), akathesia (in 5.1% patients), increased sleep (in 3.4% patients) and tremor (in 3.4% patients). The most common organ system involved was neurological (44.0%) followed by metabolic/endocrine (25.0%) and gastrointestinal (14.0%). Out of total 100 ADRs, 4 ADRs resulted in altered serum biochemistry including Hyperprolactenemia, Agranulocytosis, Liver function test dysfunction and Dyslipidemias accounting for 4% of total ADRs.

Keywords: Adverse drug reactions, Antipsychotic drugs, Serum biochemistry.