Abstract

FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE SOLID DISPERSIONS USING HYDROPHILIC CARRIER

V.N.S. Jahnavi, S. Bhagya Laxmi, B. Sireesha, K. Geetha Sri, K. Preethi Sobha Sri, P.M.M. Naga Lakshmi Varma* and K. Padmalatha

ABSTRACT

The main objective of this study was to investigate the dissolution behaviour of D-lansoprazole Solid dispersion which was prepared using Mannitol as hydrophilic carrier by Fusion method and solvent evaporation method. The solubility studies, Fourier transform infra-red (FTIR) spectroscopy, percentage practical yield, drug content and in vitro drug release studies were evaluated. The Solid dispersion was prepared in 1:1, 1:2 and 1: 3 weight ratios of the drug to carrier. FTIR studies showed that there was no interaction between the drug and carrier. In vitro release profiles of all Solid dispersions (F1 to F6) were comparatively evaluated and also compared with pure lansoprazole. Among the Solid dispersions, F6 (1:3) using Mannitol showed maximum drug release of 100.2% compared with the other formulations. So, the solid dispersion containing Mannitol (1:3) by solvent evaporation method may offer suitable formulation because of its faster drug release among all formulations. The development of solid dispersion of lansoprazole could be a promising approach to enhance its dissolution rate and solubility property, which may subsequently minimize the variation in its bioavailability.

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