Abstract

MULTIFACETED MESOPOROUS SILICA NANOPARTICLES: SURFACE ENGINEERED PLATFORM IN THERANOSTIC DRUG DELIVERY

Pandit Shubham R.* and Pande Vishal V.

ABSTRACT

The toughest challenges in the field of medicine are the effective and efficient drug delivery to the infected cells or tumor cells with minimum untoward or toxic side effects. In the absence of properties like specificity and solubility of drug molecule, patient need significantly high doses of the drug to achieve the desired therapeutic effect for the disease treatment. To overcome this issue, various drug carriers are available in the drug delivery system, which help in releasing the therapeutic drug to the desired site. For this purpose, mesoporous silica nanoparticles (MSNs) are found to be biocompatible, chemically and thermally stable nanoparticles. Their unique structural properties permit the loading of drug and facilitate controlled delivery of drug to the target site. During recent years research on MSNs has been extensively increased due to flexibility of loading the drug as per the need of patient. Since 2001, when MCM-41 was first proposed and later on SBA-15 and MCM-48 as drug carrier for modified drug delivery system. Morphological characteristics of MSN like pore size, pore volume, particle size, surface area, pH and loading capacity of drug are widely effects the MSNs, when altered. Meanwhile, surface functionalization of MSNs using organic and inorganic group elaborates the release of drug to the targeted site. This review article also deals with the recent research on synthesis methods of MSNs and their applications in the field of medicine, imaging, diagnosis, cellular uptake, targeted drug delivery, cell tracing and bio-sensing.

Keywords: Mesoporous silica, Theranostic, Biosensing, MCM-41, SBA-15.