Abstract

DEVELOPMENT AND EVALUATION OF SOLID LIPID NANOPARTICLES OF CHLORZOXAZONE

Sowmya Sree CD, Ashok Kumar P.*, Manjunath K. and Suresh V. Kulkarni

ABSTRACT

The purpose of the present study was to design and evaluate Chlorzoxazone solid lipid nano-particles. It was prepared by using lipid such as GMS, Tristearin, Compritol with surfactant like Tween 80, Poloxamer and Soy lecithin used as a stabilizer, the method used was hot melt homogenisation followed by ultra sonication. FTIR studies showed that there was no interaction between drug and lipid used. The formulated chlorzoxazone SLNs are characterized for drug, particle size, zeta potential, polydispersity index, entrapment efficiency, drug content and invitro drug release. The result showed particle size of chlorzoxazone SLNs ranged from 27.1 to 97.93 nm, zeta potential ranged from -27.2 to -38.8mV and PDI were within the range of 0.18 to 0.625. Entrapment efficiency of all the formulation were ranged from 70.5 to 96.2. The optimised formulation (F5) showed good cumulative percentage release at the end of 24 hours and percentage release kinetic showed that the release was Higuchi model diffusion controlled. The “n” value was found to be 0.546 obtained by Korsmeyer-Peppas model which indicated the release mechanism was anomalous non-Fickian diffusion.

Keywords: Chlorzoxazone, solid lipid nanoparticles, in-vitro drug release, FTIR.