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*Gupta Shikhar k, Soni Girish C. Jain S.K.

Institute of Pharmacy, Bundelkhand University, Jhansi 284128. U.P. India.


The improvement of nitazoxanide bioavailability by complexation with chemically modified cyclodextrins (CyDs) has been exploited to analyse the drug/macrocycle binding affinity by a conventional method with new useful measures. Formulation were investigated in aqueous medium and in presence an amount of β-cyclodextrin at different host/guest molar ratios. The increase in solubility could be attributed to the possible masking of hydrophobic groups of Nitazoxanide, by increasing the wetting of the drug, and/or by decreasing the crystallinity of the drug. The percent drug release data from various formulations of inclusion complexes was found in the range of 50.480.98% to 94.470.46% within 120 minutes. The pure drug exhibited only 33.85 0.19% to 35.4 0.72% of release. The drug release profile of the formulations DSP1, DSK1, DSE1, and DSC1, in S.G.F.was found to be 64.410.43%,93.640.34%,92.760.64% and 85.880.72% respectively,whereas in 7.4 pH buffer it was found to be 67.410.29%, 94.470.46%, 87.850.66% and 82.800.65% respectively which are much better than other formulations prepared by their respective methods. The complexes prepared by different methods help to improve aqueous solubility, in-vitro and in-vivo release profiles. Overall, kneading system (DSK1) showed superior dissolution properties when compared to other methods used. These findings are extremely important from a commercial point of view as the prepared complexes remove the drawback of poor dissolution profile of Nitazoxanide.

Keywords: Cyclodextrin, Bioavailability, Crystallinity, Kneading system.

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