Abstract

FORMULATION AND EVALUATION OF RAPID DISSOLVING ORAL THIN FILMS OF CETIRIZINE HYDROCHLORIDE

G. Mamatha* and Gunnam Sailaja

ABSTRACT

Fast dissolving dosage forms are gaining popularity in recent time, as this dosage forms require no water for administration,cetrizine hydrochloride is widely used in allergic induced asthama.The aim of present work was to develop a rapidly dissolving oral film with good mechanical properties, instant disintegration and dissolution. Solvent casting method was used to prepare oral films, the polymers selected were HPMC 5cps and HPMC 15cps. Polythelene glycol 400 was the plasticizer used and aspartame was the sweetener. Eight batches of films with drug were prepared using different polymer concentrations. The resultant films were evaluated for weight variation, content uniformity, folding endurance, thickness, % moisture content, % moisture loss, in- vitro disintegration and in- vitro dissolution. The optimized film (F1) has disintegrated within 49seconds. The percentage release was varying with the concentration of polymer. The films made with HPMC 5cps 200mg (F1) released 96.84% of drug in 7min, which was the best release amongst all.

Keywords: Cetirizine hydrochloride, HPMC 5cps, HPMC 15cps.Polythelene glycol 400, aspartame.