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Abstract

FORMULATION AND EVALUATION OF EZETIMIBE/SIMVASTATIN TABLETS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA

Rajaguru R.*, Badhvath Raju B., Shivaji T., Sai Priya R. and Revathi G.

ABSTRACT

The objective of the present study was to develop an effective formulation of Ezetimibe/ Simvastatin The hydromethylglutaryl coenzyme A (HMG CoA) reduc-tase inhibitors, “statins,” have been remarkably effective inreducing low-density lipoprotein (LDL) cholesterol concentration, decreasing the incidence of coronary heart disease (CHD) and stroke, and extending survival Statins inhibit the synthesis of cholesterol primarily in the liver.Ezetimibe API solubility Test, Ezetimibe/Simvastatin Tablets were prepared by wet granulation methodusing A total of Seven formulations were prepared and the granules were evaluated for Precompression parameters such as Angle of repose, Bulk density, Tapped density, Compressibility Carr’sindex and Hausner’s ratio. And Post compression parameters the formulated tablets were evaluated for Weight variation, Thickness, Hardness, Friability, Disintegration Test and Dissolution Test. The results showed that all the physical parameters were within the acceptable limits.The In vitro release study of formulation F2 showed 98.62%drug release at the end of 30 min.F4 showed 98.83%drug release at the end of 30 min.F7 showed 98.41%drug release at the end of 30 min.

Keywords: (HMG CoA), Low-density lipoprotein (LDL), Cholesterol, Wet granulation method.


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