Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF ETHOSOMAL GEL FOR EFFECTIVE TREATMENT OF ACNE

Soubhagya Tiwari*, Usha Vishwakarma, Surendra Jain and Nishi Prakash Jain*

ABSTRACT

Ethosomes are the modified forms of liposomes that are high in ethanol content. The ethosomal system is composed of phospholipid, ethanol and water. They can penetrate the skin and enhance compound delivery both to deep skin strata and systemically. Ethosomes also offer a good opportunity for the non-invasive delivery of small, medium, and large sized drug molecules. The aim of the present study was to statistically optimize the vesicular formulations Ethosomes for enhanced skin delivery of a model drug of anti-inflammatory category, which was potent candidate for the treatment of acne. Ethosomes is vesicular drug delivery system that increases the permeability of drug which promote researchers to choose as formulation development which maintain adequate concentration to treat skin disease. In conclusion, ethosomal formulations of AzA were successfully prepared, optimised and evaluated. Thin film hydration method exhibited good results in terms of % Entrapment efficiency, % Drug diffused. Vesicle size obtained was suitable. Ethosomal gel prepared was superior and efficient as compared to conventional formulations based on the in-vitro, ex-vivo release profiles and antimicrobial activity. Also, formulated gels provided sustained release of the medicament. The dosage form prepared was non-irritant to the skin and therefore, can be used successfully as a topical formulation. AzA vesicular based delivery systems are hence promising in the treatment of acne and vesicular systems can be employed topically in the treatment of various skin disorders.

Keywords: liposomes, Ethosomal gel, delivery system, acne and vesicular systems.