Abstract

METHOD DEVELOPMENT AND VALIDATION OF TRAZODONE HYDROCHLORIDE (HCL)-REVIEW

Madhu S. Shewale*, Suhas Siddheshwar and Mahesh Kolhe

ABSTRACT

Trazodone Hydrochloride (TRZ) is a well-known chemical compound that is used as an antidepressant that belongs to selective serotonin reuptake inhibitors (SARI). This medication is used to treat depression. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression. Trazodone is available in the form of 25 mg, 50 mg, 100 mg, 150 mg, and 300 mg tablets for oral ingestion. An extended release formulation at 150 mg and 300 mg as tablets is also available. The existing available literature reports explain there are different analytical method available for estimation of trazodone hydrochloride single as well as combination with other antidepressant. the different analytical method include RP-HPLC, UV, Spectrophotometric method are available for estimation of trazodone hydrochloride the existing available literature report do not include any systematic assay method for analyte quantification to reflect the accurate purity characteristic of sample to get average accurate results, hence there is a scope to develop assay method for estimation of trazodone hydrochloride dosage form

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