Abstract

ORIGIN, MECHANISM, TREATMENT AND CLINICAL THERAPIES ON COVID-19

Pallavi R. Ghogare*, Pratima S. Ladda, Pooja L. Choundhe, Shubhangi S. Wayal, Vaishnavi R. Belokar

ABSTRACT

The Coronavirus 2019 (Covid-19) is an acute respiratory disease, caused by a novel corona virus (SARS-CoV2, previously known as 2019-nCoV) which originate in wuhan(China) and spread throughout world. China notified the outbreak to the World Health Organization(WHO) on December 31,2019. The virus was identified as a coronavirus on 7th January which had greater than 95% homology with the bat coronavirus and greater than 70% similarity with the SARS CoV. Novel corona virus (Covid-19) considers as a pandemic by World Health Organization (WHO) on March 11, 2020. The number of COVID-19 infected patients as well as the death numbers increases daily worldwide. As of today, 11th May, 2020, there are 4,181,218 corona virus cases, with 2,83,876 deaths has been recorded. At present, no effective treatment or vaccine is available for COVID-19. However, A randomized multicentre controlled clinical trial is currently underway to assess the efficacy and safety of abidole in patients with COVID-19. The infection of COVID-19 is highly seen in heart and lungs as it is triggered by the binding of the spike proteins of virus to ACE-2 mostly present in heart and lungs. Several options can be proposed to control or prevent emerging infections of 2019-nCoV, including broad spectrum antiviral drugs like Nucleoside analogues and also HIV protease inhibitors, vaccines, monoclonal antibodies, plasma therapies, peptides, interferon therapies and small-molecule drugs.

Keywords: COVID-19, Virus, Infection, Antibody, Therapy, Vaccine.