Abstract

A REVIEW STUDY ON DETERMINATION OF ABACAVIR AND LAMIVUDINE BY USING DIFFERENT ANALYTICAL METHODS IN BULK AND TABLET DOSAGE FORMS

M. Bala Krishna*, M. Swapna Sri and K. Padmalatha

ABSTRACT

Abacavir and lamivudine are well-established nucleoside reverse-transcriptase inhibitors available as a once-daily FDC. Hepatic function should be monitored closely in HIV/HBV co-infected patients who discontinue lamivudine-containing products as severe acute exacerbations of HBV have been reported. This is a different types of methods by using for the determination of abacavir and lamivudine accurately it shows the simple rapid, accurate, precise, and reproducible validated for the different analytical methods was developed for the determination of abacavir and lamivudine in bulk and tablet dosage forms. An analytical technique is a method that is used to determine the concentration of a chemical compound or chemical element. There are a wide variety of techniques used for analysis, from simple weighing (gravimetric analysis) to titrations (titrimetric) to very advanced techniques using highly specialized instrumentations. The most common techniques used in analytical methods are titrimetry, potentiometry and voltammetry, spectroscopy, chromatography.

Keywords: abacavir and lamivudine, nucleoside reverse-transcriptase inhibitors, titrimetry, potentiometry, spectroscopy and chromatography.