Abstract

A REVIEW ON PHARMACOLOGICAL PROFILE OF PHENYTOIN AND THEIR DERIVATIVES

*Rahul Chauhan, Pooja Saini, Richa Choudhary and Utkarsh Verma

ABSTRACT

Purpose: Phenytoin is an aromatic heterocyclic compound, Antiepileptic Properties which is used as Anti-convulsant agent but also used in the CNS disorder drugs. Phenytoin was first made in the year 1908 by the German chemist Heinrich Blitz and found useful for seizure in 1963. But as a drug Phenytoin is an oral and injectable anti-seizure medication was focused in 1908s, as 10-substituted derivatives. Along with this phenytoin also has anti-seizure, toni-clonic seizures, and focal seizures effect. Most prominent use of these derivatives is as tranquilizer because it has defused an anti-epileptic effect. It is also reported to have anti-cancer, antitubercular, anti-inflammatory, anticonvulsant, Anti-arrhythmic, Skeletal muscle relaxant effects. The biological evaluation for the CNS agent activity has been performed. From the biological investigation, it is found that out of all the synthesized two compounds show potent CNS agent activity. Conclusion: The literature proves that Phenytoin show effects like cytotoxic activity, antiarrhythmic activity, anticonvulsant, CNS agent etc. From result and discussion we come to know that the substitutions on aromatic amine have great significance on yield value. The percentage yield is increased by substitution at para and Meta position of the ring whereas it decreases in case of ortho substitution due to steric effect. The steps included condensation followed by N Acylation, Vilsmeier-Haack reaction or Thermal cycloaddition. This article provides various methods to prepare more derivatives of Phenytoin to explore more activities of phenytoin.

Keywords: Phenytoin, Heterocyclic compound, CNS Agent.