A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF SOFOSBUVIR AND DACLATASVIR BY HPLC
Akash B. Pawar*, Prof. Hemlata S. Bhawar and Prof. Amol S. Dighe
ABSTRACT
The main aim of this review article is emphasizing on development and validation protocol which will used to develop and validate accurate, simple, selective and specific spectrophotometric methods for the determination of sofosbuvir and daclatasvir in pure and in their dosage forms. Thus it is necessary to develop methods for the analysis with the help of many analytical techniques which are available for the estimation of the drugs in combination. The analyst were determine the Specific, accurate, simple, selective and stability-indicating RP-HPLC method is developed and validated for simultaneous determination of Sofosbuvir and Daclatasvir in pure and in their dosage forms.
Keywords: Sofosbuvir, Daclatasvir, RP-HPLC, UV- Visible Spectrophotometry.
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