Abstract

A COMPUTATIONAL APPROACH OF DRUG DISCOVERY BASED ON MEDICALLY AND CULINARY IMPORTANT NATURAL PRODUCTS AS LIGANDS FOR COVID-19

Abhilash Mullasseril*

ABSTRACT

This study concentras the active principles of certain natural products and their plaussible activities to inhibit/interact with the main protease of SARS CoV-2 causing COVID-19 using the in silico methodos of drug designing. The process of drug designing based on various natural products that might act as possible leads of new drugs to inhibit the protease of SARS CoV-2 effectively is one among the contemperory challenges in front of the Medicinal Scientists. So far there exists no effective treatment or a complete vaccine for protecting the human society from this pandemic. The selection of moleccules of natural origin for docking studies was carried out purely random basis but supported with the available scientific literatures. Many of the lead candidates were showed promising results and were found as par with the modern antivirals prescribed under compassionate therapies.

Keywords: Drug designing, SARS CoV-2, COVID-19, Chloroquine, Hydroxychloroquine, Antivirals.