Abstract

SCREENING FOR ANTIDEPRESSANT ACTIVITY FROM AQUEOUS BARK EXTRACT OF SYMPLOCOS RACEMOSA

Shaik Karishma*, R. B. Desireddy, K. Sri Nagaleela, K. Navyasri, K. Hema Latha and K. Saikumar Naik

ABSTRACT

The main objective of the study to evaluate the Anti-depressant activity of bark extract of symplocos racemosa in Forced swim test (FST), Tail Suspension test (TST) in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. EESR did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, EESR showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of EESR significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, EESR showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine, EESR was not acting through Adrenergic system.

Keywords: Symplocos racemosa, Antidepressant activity, Forced swim test, Tail suspension test.