Abstract

SYNTHESIS AND EVALUATION OF TOLBUTAMIDE ASSISTED BY MICROWAVE OVEN

Ajay Dongarwar*, Priti Bisen, Priyanka Jonai, Rajshree Chindhalore, Nitin Indurwade and Tulsidas Nimbekar

ABSTRACT

Microwave synthetic methods were devised for three lab reactions. The synthesis of tolbutamide. These reactions are all done in either general chemistry or organic chemistry. Under conventional heating methods, the tolbutamide synthesis requires heating at 55 °C for 30 minutes. The proposed microwave methods provide shorter reaction times (10 min. at 175 watts) while maintaining similar, if not better, yields. The tolbutamide synthesis was shortened to 7 minutes, and the Claisen condensation was shortened to 4.5 minutes. The microwave method produced 70.70% yield for tolbutamide, while conventional yield was 50.50%.

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