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Abstract

SYNTHESIS AND EVALUATION OF MUTUAL PRODRUGS OF IBUPROFEN AS NON STEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIOXIDANTS

Datta M. Avhad*, Dinesh R. Chaple, Alpana J. Asnani, Shrikant Mohurle, Kumar Pratyush and Ruchita R. Tale

ABSTRACT

Mutual prodrug are form of prodrug in which two pharmacologically active compounds are in such a manner that one drug acts as carrier for each other. Inflammation is usually defined as the series of changes that occur in living tissues following by injury and is associated with redness, itching and swelling. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for treatment of the inflammation. These drugs are used alone or in combination with other drugs. These drugs are associated major side effects like gastro intestinal irritation due to presence of carboxylic acid group in the structure. The local generation of various „reactive oxygen species‟ play a significant role in the formation of gastric ulceration associated with NSAIDs therapy. This indicates antioxidants may prevent gastric ulceration due to NSAIDs. Mutual prodrugs of Ibuprofen were planned for treatment of inflammation along with antioxidants property. Ibuprofen as mutual prodrugs and their physiological characterization of synthesized products were carried out Analgesic, anti-inflammatory and ulcerogenic activities were evaluated for synthesized compounds. The synergistic property of mutual prodrugs leads to potent biological actions i.e. treatment of inflammation.

Keywords: Mutual prodrug, NSAIDs, Reactive oxygen species, Ibuprofen, ulcerogenic.


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