Abstract

AMELIORATING EFFICACY OF ASCORBIC ACID AGAINST ENDOSULFAN INDUCED HEMATOLOGICAL PARAMETERS IN ALBINO MICE

P. Vijaya*, Suman Sharma, Maninder Singh Sidhu and Amar Santosh Dhalla

ABSTRACT

The present study has been undertaken to evaluate the protective role of ascorbic acid against endosulfan induced toxicity on hematological parameters in albino mice. Albino mice were divided into three groups. Group I mice were kept as control. Group II animals were administered a single dose of endosulfan (1mg/kg bw) intraperitoneally. Group III animals were injected a single dose of endosulfan followed by a chronic dose of ascorbic acid (100mg/kg bw). Autopsies were done at the intervals of 7, 14, 21 and 28 days post treatment. Endosulfan treatment leads to decrease in RBC counts, haemoglobin, haematocrit, platelet count and neutrophils whereas significant increase in amount of white blood cells (WBC), lymphocytes, monocytes, eosinophils and basophils were observed in comparison to controls. Vitamin C administration ameliorated all the hematological changes induced by endosulfan in mice.

Keywords: Endosulfan (E), Ascorbic acid (AA) or Vitamin C and haematological parameters.