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Abstract

ESTIMATION OF GUAIFENESIN BY UV VISIBLE SPECTROPHOTOMETER IN PHARMACEUTICAL SUBSTANCES AND PHARMACEUTICAL PRODUCT

Manasa Merugu*, B. Sai Teja, B. Kavya Sree, B. Pravallika and Ch. Navya Prashanthi

ABSTRACT

The present research work discuss the development of UV spectroscopic method for the estimation Guaifenesin. Simple, specific, accurate and cost effective spectroscopic method has been developed for the estimation of guaifenesin in bulk as well as formulation. The optimum condition for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 209 nm. The validation was performed as per ICH guidelines for linearity accuracy, precision, LOD and LOQ. The method show high sensitivity with linearity in the range of 50-150 μg/ml and shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.999. The regression of curve was y = 0.244x + 0.246. The precision of method was found to be good. The percentage recovery was found to be 99.57%. Good reproducibility was observed from precision with RDS <2%. The proposed method will be suitable for analysis of guaifenesin in bulk as well as pharmaceutical formulations in quality control purpose. Thus it was concluded that the proposed method is new, simple, cost, effective, safe, accurate, precise and environmental friendly.

Keywords: Guaifenesin UV spectroscopic, sensitive, validation, ICH guidelines.


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