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Abstract

DEVELOPMENT AND VALIDATION OF BULK AND DOSAGE FORM OF MEFENAMIC ACID USING UV SPECTROPHOTOMETER

Amneet Kaur and Kajol*

ABSTRACT

The present research gives the method validation of mefenamic acid dosage by UV spectrophotometer. Mefenamic acid is having low water solubility it was dissolved in methanol and the calibration curve was obtained after preparing the different dilutions from the standard stock solution. The method validation was done as per ICH guidelines and the results of the different parameters were observed. the linearity of the drug was maintained from 2-10 μg/ml. The further accuracy and precision parameters were also done on the sample. Along with this the parameters like LOD, LOQ, robustness, and ruggedness were also performed and is well explained in the research. The calibration curve is showing the regression coefficient of 0.995 and it follows Beer-lambert’s law. The research helps analyze the optimization of the drug using the UV spectrophotomter

Keywords: Validation, mefenamic acid, UV spectrophotometer, ICH.


[Full Text Article]

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