Abstract

DESIGN AND OPTIMIZATION OF DILTIAZEM MATRIX TABLETS AS SUSTAINED RELEASE

Y. Phalguna*, Nagajyothi, Mrinmay Das and Swetha Pothula

ABSTRACT

In present day pharmaceutical innovation the continued and controlled medication exchange frameworks are the more celebrated frameworks. Presentation of framework measurements structure as supported release(SR) has given another leap forward for novel dynamic substance move framework in the field of Pharmaceutical innovation. Diltiazem was generally indicated for the management of chronic stable angina. The sustained release (SR) form of the drug has been found to result in better compliance. The medication and the excipient compatability examines are finished by utilizing the FTIR studies. Dry granulation method with the help of excipients was attempted for the formulation development of matrix tablets of Diltiazam. The tablets were characterized for various parameters like bulk density, tapped density, Angle of repose, Hauner’s ratio, carr’s index. All results are within the limits and tablets were evaluated for thickness, weight variation, friability, Disintegration and dissolution studies. The formulation F7 shows the sustained-release matrix tablets of diltiazem.

Keywords: Diltiazem, Matrix tablets, HPMC, EC, Dry granulation, Invitro studies.