Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

MW INDUCED SYNTHESIS OF SOME PYRIMIDINE LINKED THIADIAZOLES AND STUDY OF THEIR ANTIMICROBIAL PROPERTIES

Kalpana A. Palaspagar and Pradip P. Deohate*

ABSTRACT

The series of some interesting heterocyclic scaffolds (5-aryl/alkylamino-[ 1,3,4]-thiadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)- amines (6) has been synthesized by the intramolecular cyclization of (4,6-dimethyl-pyrimidin-2-yl-amino)-acetic acid N-(N’-aryl/alkylthioamido)- hydrazides (5) using o-phosphoric acid. The required hydrazides (5) were prepared by the interaction of (4,6-dimethylpyrimidin- 2-yl-amino)-acetic acid hydrazide (3) with differently substituted N-aryl/alkyl-isothiocyanates (4) under microwave conditions at 800 W. The hydrazide (3) was synthesized by reacting 2- amino-4,6-dimethyl-pyrimidine (1) with ethyl chloroacetate to give ethyl-(4,6-dimethyl-pyrimidin-2-yl-amino)-acetate (2) followed by its condensation with hydrazine hydrate in ethanol medium by microwave irradiation. The formation of desired compounds was checked by TLC and their structural interpretation was done by chemical transformations, elemental analysis, equivalent weight determination and spectral studies viz. IR, 1H-NMR, mass spectroscopy. The synthesized compounds were assayed for their antimicrobial properties.

Keywords: Microwave, pyrimidine linked thiadiazolidines, biological activities.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More