Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF NAIL FORMULATION OF KETOCONAZOLE FOR THE TREATMENT OF ONYCHOMYCOSIS

Devyani Srivastva*, Tarun Kumar Sharma, Sumit Sharma, Rakshit and Bhandari Neeraj

ABSTRACT

The impact of hydration on the permeation of the antifungal drug ketoconazole through silicon membrane in vitro was evaluated in diffusion cell studies. Silicon membrane was treated with phosphate buffer 7.4. Diffusivities estimated from the data and the associated silicon membrane contents can are described by using double beam UV Spectrophotometer. Bioadhesion is one of the key factors to be considered in development of a successful transnail drug delivery system in onychomycosis. A full size nail clipping was fixed on p/6 probe of texture analyzer (TA.XT plus stable, micro system, UK) was used for adhesivity study. Therefore, formulations or treatments, which increase nail hydration, have potential to improve topical therapy for onychomycosis, if a favorable balance between drug delivery and growth conditions for the dermatophytes can be achieved.

Keywords: Onychomycosis, Ketoconazole, Nail, diffusion.