Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF NAIL FORMULATION OF KETOCONAZOLE FOR THE TREATMENT OF ONYCHOMYCOSIS

Devyani Srivastva*, Tarun Kumar Sharma, Sumit Sharma, Rakshit and Bhandari Neeraj

ABSTRACT

The impact of hydration on the permeation of the antifungal drug ketoconazole through silicon membrane in vitro was evaluated in diffusion cell studies. Silicon membrane was treated with phosphate buffer 7.4. Diffusivities estimated from the data and the associated silicon membrane contents can are described by using double beam UV Spectrophotometer. Bioadhesion is one of the key factors to be considered in development of a successful transnail drug delivery system in onychomycosis. A full size nail clipping was fixed on p/6 probe of texture analyzer (TA.XT plus stable, micro system, UK) was used for adhesivity study. Therefore, formulations or treatments, which increase nail hydration, have potential to improve topical therapy for onychomycosis, if a favorable balance between drug delivery and growth conditions for the dermatophytes can be achieved.

Keywords: Onychomycosis, Ketoconazole, Nail, diffusion.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More