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  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

REPOSITIONING NSAIDS AND CURCUMIN FOR CHEMO PREVENTION OF LUNG CANCER

Archana Moon*, Susmita Patel, Bhagyashree Fuke, Kanchan Kukreja, C. Shivani Sri, Tejswini Saonerkar, Prachi Raut, Rita Lakkakul and Ninad Nagarkar

ABSTRACT

Non-Steroidal Anti-inflammatory Drugs (NSAIDS) are the most prescribed analgesic medication for many conditions due to their analgesic, anti-inflammatory and antipyretic properties. NSAIDs have the ability to inhibit the enzyme cyclooxygenase (COX), thus, targeting the prostaglandin (PG) pathway, which can result into prevention and treatment of cancer. This study aims to reposition NSAIDs for management of lung cancer, as it is cost effective and less time consuming since clinical trials of the drugs is already completed. Based on previous findings, five NSAIDs were selected from different classes’ viz., diclofenac, naproxen, ibuprofen, tolfenamic acid, and celecoxib to investigate their chemo-preventive effects. We studied the cytotoxic effects of NSAIDs and investigated the synergistic effect of NSAIDs with curcumin on lung cancer cell line A549. Cytotoxicity assays were followed by in-silico docking studies. Studies on repositioning of drugs would be beneficial in developing non-invasive cancer management modalities.

Keywords: Repositioning NSAIDs, Cytotoxicity, in silico Docking.


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