Abstract

THE PHYTOCHEMICAL INVESTIGATION OF PHYLLANTHUS AMARUS FOR ANTIDIARRHOEAL ACTIVITY

Priyanka Chaurasia*, Shubham Chaurasia and Prashant Gupta

ABSTRACT

Diarrhoea is one of the leading causes of preventable death in developing countries and mainly affects children and infants. Diarrhea occurs in whole world and causes four percentages of all death and five percentages of strength defeat to disability. The antidiarrhoeal effects of the aqueous extract of phyllanthus amarus were evaluated in rats. Antidiarrhoeal activity was screened by using castor oil induced diarrhea, charcoal meal assay and PGE2 induced assay the extracts of leaves phyllanthus amarus exhibited pronounced antidiarrhoeal effects in dose dependent manner. Aqueous extract was prepared and phytochemical analysis revealed the presence of Flavonoids and tannins or major constituents like flavonoids, tannins, terpenes are reported to possess antiulcer and antidiarrhoeal activity. From the acute toxicity study of the aqueous extracts was establish to be non-lethal up to 2000mg/kg body weight of animals. Aqueous extract of Phyllanthus amarus possessed significant anti-diarrhoeal activity against different diarrhoeal induced models.

Keywords: Antidiarrhoeal Activity, Intestinal Motility, Phyllanthus amarus, Dysentery, Castor Oil, Enterotoxin, PGE2.