Abstract

ELECTROANALYTICAL STUDY OF AMPYRONE BY DIFFERENTIAL PULSE VOLTAMMETRY IN HUMAN PLASMA AND URINE SAMPLES

Arunkumar T. Buddanavar, Jayant I. Gowda and Sharanappa T. Nandibewoor*

ABSTRACT

An analytical method for the determination of Ampyrone drug using cyclic and differential-pulse voltammetry has been developed. The oxidation process was shown to be irreversible over the pH range 3.0−9.2. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for the determination of Ampyrone. The number of electrons transferred in the oxidation process was calculated and a probable oxidation mechanism is proposed. In the range of 1.0 × 10−7 – 8.0 × 10−7 M, the current measured by differential-pulse voltammetry as a function of the concentration of Ampyrone exhibited a good linear relationship with a detection limit of 7.44 ×10-8 M . The proposed method was applied to the determination of Ampyrone in real samples.

Keywords: Voltammetry, Ampyrone, Electro-oxidation, Human plasma sample.