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Abstract

FORMULATION, EVALUATION AND OPTIMIZATION OF ORO DISPERSIBLE TABLETS OF DILTIAZEM HYDROCHLORIDE 120 MG

Jameel Abbas*, Dr. Malik Tauheed Ahmad, Dr. Pathan Imran Khan, Dr. Abdul Rehman Shaikh, Dr. Masarat Begum and Dr. Shaikh Muzaffar Ahmad

ABSTRACT

The concept of Mouth Dissolve Drug Delivery System emerged with an objective to improve patient’s compliance. These dosage forms rapidly disintegrate or dissolve to release a drug as soon as they come in contact with saliva in oral cavity, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients. Difficulty in swallowing conventional tablets and capsules (Oral solid dosage form) in common among all age groups especially on elderly and dysphasic patients. Elderly patients may find the administration of the conventional oral dosage forms difficult as they regularly require medicines to maintain healthy life. Children may also have difficulty in ingesting because of their under developed muscular nervous system. The problem of swallowing tablets is also evident in travelling patients who may not have ready access to water. Aforementioned problems can be resolved by means of Mouth Dissolving Tablets. Some tablets are designed to dissolve in saliva within few seconds, and are true fast- dissolving tablets .Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed as fast disintegrating tablets, as they may take about to disintegrate completely. The most common preferred route is oral rout of administration. Today oro-dispersible tablet from novel drug delivery system gain importance from patient. Which is administer to the patient to control the attack of angina or hypertension, but for immediate control, Oro-dispersible tablet is oral solid dosage form in which the tablet gets dispersed in oral cavity in absence of water. Various manufacture are formulated this formulation by various method. The most importance thing in this formulation are masking of taste of drugs. Generally oro-dispersible tablet are prepared by direct compression method. Dry granulation, wet granulation, Spry drying is the various methods for preparation of oro-dispersible tablet. Oro-dispersible tablet generally contains filler, glidant, anti-adherent super disintegrate, sweetener and resins. Evaluation parameter includes hardness, friability, wetting time, moisture uptake, disintegration test, and dissolution test. Wetting time, Disintegration time, and Dissolution test is directly proportional to the hydrophobic ingredient added for lubrication, anti-adherent, Glidant action. These hydrophobic ingredients are Magnesium Stearate. To oppose the action of magnesium Stearate, hydrophilic additives are incorporated viz Sodium lauryl sulphate, Cross Carmillose sodium, sodium starch glycol ate are added.

Keywords: Oro-dispersible tablet, wetting time, Dissolution test.


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