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Abstract

SOLUBILITY ENHANCEMENT OF BCS CLASS –II DRUG BY USING NOVEL SUPER DISINTEGRANTS

Dr. Sathya Surya Prasad Ch.*, P. Roshini Priya, M. Sahithya Deepthi, S. Sai Lakshmi, A. Naga Lakshmi

ABSTRACT

The present research going on in the world to enhance the solubility of poorly soluble drugs (BCS–II). Nebivolol is used as an antihypertensive drug but it goes under first pass metabolism due to which has low solubility and low bioavailability. Fast onset of action is major concern in the management of hypertension. Therefore the aim of this study is to formulate six formulations of Nebivolol 250 mg were formulated by direct compression technique using different natural super disintegrating agents (Banana powder & SSG) along with other ingredients are micro crystalline cellulose (MCC), mannitol, magnesium stearate and sodium saccharin. Before the formulation the granules are evaluated by pre-compression studies like density, flow properties, FT-IR and DSC. The obtained tablets were evaluated with different post-compression parameters like hardness, friability, thickness, weight variation, In-vitro disintegration studies and In-vitro dissolution studies. The formulation F6 was selected as an optimized formulation because it gives best results in terms of In - vitro drug release in a fast release manner and best fitted to first order model with r value of 0.999.

Keywords: Nebivolol Hydrochloride, Sodium Starch Glycolate, Banana Powder, microcrystalline cellulose, Mannitol and sodium saccharin.


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