Abstract

TO STUDY EFFECT OF VARIOUS POLYMERS FOR DEVELOPMENT OF PHASE TRANSITION SYSTEMS FOR NASAL DELIVERY

Chetan Y. Kadam*, Nishan N. Bobade, Shrikant D. Pande, Kiran K Tapar

ABSTRACT

Phase transition drug delivery systems are novel polymeric formulation which is generally present in sol state and become gel in human body. the present research work is study effect of various polymer such HPMC K4M, sodium alginate, carpool, gellum gum on performance of phase transition systems for nasal delivery using Rivastigmine Tartrate as model drug. The prepared formulations were evaluated for pH, gelatin time, gelatin temperature, viscosity, muco-Adhesion study, release and permeation study. It was concluded that polymer viscosity building capacity affect performance of phase transitions systems. As polymer concentration in formulation was increased viscosity of formulation increases with gelation time, gelation temperature, muco-adhesion time, stresses increase and release of drug also retarded. Viscosity building capacity polymer was found to be increasing order as HPMCK4M < carbopol

Keywords: Phase Transion, Nasal Delivery, Rivastigmine Tartrate.