Abstract

THE EFFECT OF HYDROXYCHLOROQUINE ON COVID-19 AND THE HUMAN SYSTEM

Dipak B. Khillare* Gaurav M. Prajapati and Priyanka D. Nehe

ABSTRACT

Hydroxychloroquine is a more soluble and less toxic derivative of chloroquine and having the ability to inhibit the actions of SARS-CoV-1. COVID-19 enters into the human body and affects the cells of the lung. Virus attack on the goblet cell and starts to spread the infection and the process continues killing more lungs. Chloroquine and Hydroxychloroquine are considered to be immunomodulators rather than immunosuppressants. HCQ and CQ inhibit receptor binding and membrane fusion; there include two steps for entry of the virus. The virus uses the endosomes as its main entry of mechanism. Hydroxychloroquine terminates glycosylation of ACE2. Therapeutic dose ranging from 155 mg to 310 mg, pharmacokinetic parameters were changing, which indicates linear kinetics. Hydroxychloroquine having less chance for accumulation but it had some adverse conditions like diarrhea and vomiting. World health organization permanently named the 2019-nCoV pathogen as SARS-CoV-2 and the causing disease as coronavirus disease 2019 (COVID-2019).

Keywords: SARS-CoV-2, immunomodulators, ACE2, goblet cell, receptor, pathogens.