AMELIORATIVE EFFECTS OF DIETARY POLY UNSATURATED FATTY ACIDS ON ELECTRON BEAM INDUCED ANXIETY LEVEL IN SWISS ALBINO MICE
Mahesh Bekal*, Suchetha Kumari
ABSTRACT
The whole brain irradiation causes injury to the nervous system at various levels. Omega-3 Poly Unsaturated Fatty Acids are very much essential for the growth and development of nervous system. Dietary supplementation of these nutrients will promote the development of injured neuronal cells. Therefore this study was undertaken to establish the role of Omega-3 Poly Unsaturated Fatty Acids on total brain lipid concentration, lipid peroxidation and anxiety levels in the irradiated mice. The effect of Electron Beam Radiation (EBR) on Brain Lipid Peroxidation and anxiety level were investigated in male Swiss albino mice. The study groups were subjected to a sub-lethal dose of EBR and also the Flax seed extract and Fish oil were given orally to the irradiated mice. Irradiated groups show significant elevation in anxiety levels when compared to control group, indicating the acute radiation effects on the central nervous system. But the oral supplementation of dietary PUFA source decrees the anxiety level in the irradiated group. The Analysis of Lipid peroxidation showed a significant level of changes when compared between control and radiation groups. Dietary PUFA supplementation showed a significant level of decrease in the lipid peroxidation in the irradiated groups. This study suggests that the dietary intake of PUFAs may help in prevention and recovery of Anxiety and oxidative stress caused by radiation.
Keywords: Electron Beam Radiation, Anxiety, PUFA.
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