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  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

PHARMACEUTICAL CO-CRYSTALLIZATION- A NOVEL TREND IN SOLUBILITY ENHANCEMENT OF API

*Mrs. Shweta Harshal Zalte

ABSTRACT

During development of new product, poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major issues. Cocrystalization recently emerged as interesting alternative with potential for improving the physicochemical properties of a drug substance such as melting point, tabletability, solubility, stability, bioavailability and permeability without interfering with pharmacological properties of active pharmaceutical ingredient. Pharmaceutical cocrystal is crystalline nonionic supramolecular complexes of two one being neutral molecules or an active Pharmaceutical ingredient (API) and the other a coformer. Cocrystal consists of an active pharmaceutical ingredient and a pharmaceutically acceptable coformer in the stoichiometric ratio and bonded together with non-covalent interactions in the crystal lattice. This review article focuses on systematic overview of pharmaceutical cocrystals. Differences between cocrystals with salts, solvates and hydrates are summarized along with the advantages of cocrystals, methods of preparation and evaluation, future perspective of cocrystals.

Keywords: Pharmaceutical cocrystals, solubility, bioavailability, cocrystalization.


[Full Text Article]

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