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Prof. Jeevan R. Rajguru*, Ms. Snehal D. Jadhav, Ms. Sujata S. Kurkute, Dr. Sampat D. Navale


Now day’s Recent advances in the understanding of pharmacokinetic & pharmacodynamic behaviour of drug have offer a more rational approach to the development of optimal drug delivery system. It is the rate and extent to which a drug becomes available to the target tissue after its administration. An ideally design drug delivery system delivers a specified amount of drug to target particular site at an appropriate time and rate as dictated or desired by the etiological and physiological needs of the body. Conventional Pharmaceutical Dosage forms are incapable of controlling the rate of drug delivery to target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

Keywords: New drug delivery system, Phytosome, Nanoparticles, Microsphere, Liposomes, Hydrogel, Solid Lipid Nano particles.

[Full Text Article]

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