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  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RITONAVIR: A REVIEW

Dipak Nalawade*, Dr. R. K. Godge and S. D. Magar

ABSTRACT

Ritonavir is an anti-retroviral drug used in the treatment of HIV/ AIDS. Many times, Ritonavir is used alone and in combination with many anti-retroviral drugs. So far, around seventy nine analytical methods have been reported for various studies on analysis of Ritonavir in bulk, pharmaceutical formulations and biological fluids. Aim: To abbreviate the various analytical techniques such as Chromatography, Spectrophotometry; Capillary electrophoresis for estimation of Ritonavir. Method: This article deals with the study of the various type of analytical techniques such as Chromatography, Spectrophotometry; Capillary electrophoresis and also other techniques
such as LC- MS/MS, and their applicability in analysis of Ritonavir. These techniques are either explored for the quantification, detection of metabolite and also for stability-studies of the Ritonavir.

Keywords: Ritonavir, RP-HPLC, Validation.


[Full Text Article]

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