Abstract

PHARMACOLOGICAL EVALUATION OF ANALGESIC POTENTIAL OF BYTTNERIA PILOSA LEAVES

*Yesmin Begum, Ruma and Syeda Naureen Ahmed

ABSTRACT

The aim of the current study was to evaluate the analgesic potentials of the methanolic leaf extracts of Byttneria pilosa (MEBP) belonging to the family Malvaceae, a hill tract plant, traditionally used in rheumatism. Analgesic potential of the leaf extracts of B. pilosa was evaluated using mice models by acetic acid-induced writhing (100mg/kg and 200mg/kg) and Hot plate method (25mg/kg and 50mg/kg) comparing with standard drug indomethacin. The results of the study showed that MEBP possess peripherally and centrally acting analgesic potential in mice model. In acetic acid induced writhing method, MEBP (100mg/kg & 200mg/kg) significantly (P<0.001, P˂0.05) and dose dependently reduced pain sensation with 64.07% & 80.62% inhibition as compared to standard with 55.29% of inhibition respectively. In Hot Plate method 25mg/kg MEBP also appreciably increased reaction time with 10.25%, 12.25% & 14.75% of latency and 50mg/kg MEBP increased reaction time with 11.75%, 14% & 15.5% of latency which are statistically significant (p<0.001, P˂0.05) at 60min, 90min and 120 min as compared to standard with 8%, 14.75% & 15% of latency respectively. The investigations revealed that the methanolic leaf extracts of B. pilosa possess both the presence of both central and peripheral analgesic potentials of B. pilosa leaves that potentiate the identification and isolation of responsive secondary meabolites in future.

Keywords: Analgesic, Indomethacin, Byttneria pilosa.