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Abstract

MARKERS FOR CANCER STEM CELLS IN ENDOMETRIOSIS AND ENDOMETRIUM CANCER

Mohamed Maher, Rokaya H. Shalaby*, Nawara Hashish, Ibrahim M Fakhr and Soheir Korraa

ABSTRACT

The endometrium has peculiar regenerative properties linked to the presence of adult stem cells similar to mesenchymal stem cells (MSCs). Angiogenesis promoted by MSCs could play an important role, as survival and proliferation of endometriotic tissue depend on the formation of new blood vessels. In this present study 40 patients at early stages of endometriosis vs. 20 controls whose age range 30-45 were selected. Also 40 patient with endometrium cancer vs. 20 control were selected. CD133, cytokeratin 18 (CK18), cytokeratin 19 (CK19) and nestin were investigated in tissue lesions of endometriotic tissue and cancer tissue and their mRNA expression were measured in blood. Cd133, CK18, CK19 and nestin were highly expressed in tissue lesions of endometriotic tissue and cancer tissue compared to normal. In blood there was increased expression of CD133 in endometriosis, endometrium cancer tissues compared to controls. In blood CD133 was detectable being increased in endometrium followed by endmetriosis and least in controls. This study shades the light on the role of stem cells in pathogenesis of endometriosis and endometrium cancer.

Keywords: Endometriosis, endometrial cancer, CK19, CK18, Nesting, CD133.


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