Abstract

A REVIEW ON FORMULATION, EVALUATION AND APPLICATIONS OF NANO EMULSION

Sunny* and Dr. Chitra Gupta

ABSTRACT

In pharmaceutical observation, Nanoemulsions are colloidal dispersion systems that are thermodynamically stable, composed of two immiscible liquids mixed along with emulsifying agents (surfactants and co-surfactants) to form a single phase. Nanoemulsion is one of the chief dosage forms in delivering active ingredients to the objective area which has engrossed a great attention in recent years for its application in various fields. In the pharmaceutical field, nanoemulsions have been used as a drug delivery system through various systemic routes such as oral, topical and parenteral. Nanoemulsions are submicron sized emulsions which are used under high investigation as drug carriers for improving the delivery of therapeutic agents. The small droplets size 10-200 nm, high solubilization capacity, high interfacial area, low viscosity, transparent or translucent appearance, and high kinetic stability, make nanoemulsions used for various applications. These emulsions are easily produced in large quantities by mixing a water immiscible oil phase into an aqueous phase with high stress. These are prepared from surfactants, cosurfactants or cosolvents. Various characterization techniques for nanoemulsions include determination of entrapment efficiency, particle size, polydispersity index, zeta potential as well as characterization through differential scanning calorimetry, Fourier-transform infrared spectroscopy and transmission electron microscopy. In this review various aspects of nanoemulsion are highlighted i.e. method of preparation, characterization techniques like particle size, zeta potential, polydispersity, drug content and particular importance on various application of nanoemulsion in different areas.

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