Abstract

BIO-EQUIVALENCE STUDY OF TWO ORAL DOXYCYCLINE FORMULATIONS (DOXIMYL® AND GREENDOX 35%®) IN BROILER CHICKENS

Ashraf El-Komy and Mohamed Aboubakr*

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Doximyl® and Greendox 35%® in healthy broiler chickens after oral administration of both products in a dose of 20 mg doxycycline base/kg.b.wt. Twenty four broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Doximyl®, while the 2nd group was designed to study the pharmacokinetics of Greendox 35%®. Each broiler chickens in both groups were orally administered with 20 mg doxycycline base/kg.b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration The disposition kinetics of Doximyl® and Greendox 35%® following oral administration of 20 mg doxycycline base/kg.b.wt. revealed that the maximum blood concentration [Cmax] were 3.76 and 3.51 μg/ml and attained at [tmax] of 1.06and 1.09 hours, respectively. In conclusion: Greendox 35%® is bioequivalent to Doximyl® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) was 0.97, 0.95 and 0.94 respectively. These are within the bioequivalence acceptance range. Greendox 35%® and Doximyl® are therefore bioequivalent and interchangeable.

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