Abstract

BIOEQUIVALENCE STUDY OF TWO ORAL AMOXICILLIN FORMULATIONS (AMOXY ACTIVE® AND GROWTHAMOXY®) IN BROILER CHICKENS

Ashraf El-Komy and Mohamed Aboubakr*

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Amoxy Active® and Growthamoxy® in healthy broiler chickens after oral administration of both products in a dose of 20 mg amoxicillin base/kg.b.wt. Twenty four broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Amoxy Active®, while the 2nd group was designed to study the pharmacokinetics of Growthamoxy®. Each broiler chicken in both groups was orally administered 20 mg amoxicillin base/kg.b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration. The disposition kinetics of Amoxy Active® and Growthamoxy® following oral administration of 20 mg amoxicillin base/kg.b.wt. revealed that the maximum blood concentration [Cmax] were 10.99 and 10.39 μg/ml and attained at [tmax] of 0.91 and 0.92 hours, respectively. In conclusion: Growthamoxy® is bioequivalent to Amoxy Active® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) were 0.94, 0.94 and 0.95 respectively. These are within the bioequivalence acceptance range. Amoxy Active® and Growthamoxy® are therefore bioequivalent and interchangeable.

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