Abstract

FREE RADICAL SCAVENGING AND ANTI-DIABETIC ACTIVITY OF KIGELIA PINNATA

Dhriti V1., Chowdary P. V. V., Rahul J., Vishank G., Shivaji B. Bole*

ABSTRACT

Medicinal plant plays an essential role in the management of various diseases. Kigelia pinnata commonly known as the Sausage tree, it is a multipurpose medicinal plant with many characteristics and considerable potentials. The plant has traditional uses which consist of anticancer, antiulcer, anti-aging, antioxidant, and anti malarial, in the treatment of genital infections, gynaecological disorders, renal ailments, fainting etc., this work represents the recent profile of applications of Kigelia pinnata as examined by different contemporary scientific researches. In this study, the in vitro anti-oxidant activity, anti-diabetic activity and phytochemical evaluation of four different solvent extracts, from the leaves of Kigelia pinnata were determined. Phytochemical screening of the extracts of the leaves showed the presence of flavanoids, alkaloids, etc. Antioxidant activities of these extracts were evaluated through DPPH assay, reducing power assay and phospho-molybednum assay. The anti-diabetic activities of these extracts were determined by amylase inhibition assay. The anti oxidant and anti-diabetic activity of extracts was found to be promising camparble with standard. IC50 was calculated for both antioxidant and antidiabetic activity.The results obtained showed that the leaves of Kigelia pinnata has anti-oxidant and anti-diabetic properties, which helps in providing a basis for the traditional use of medicinal plant.

Keywords: Bignoniaceae, Kigelia pinnata, anticancer, anti-oxidant, anti-diabetic, DPPH.